The copper(I)-catalyzed radical cascade trifluoromethylation/cyclization reaction of N-allyl-2-arylindoles and Togni reagent (II) was developed to achieve diverse CF3-substituted indolo2,1-aisoquinoline (benzo4,5imidazo2,1-aisoquinoline) derivatives in this synthesis. The main features of this strategy include a wide substrate scope, good functional group tolerance, and moderate to good yields, which provide a valuable strategy for the synthesis of trifluoromethylated indolo2,1-aisoquinoline (benzo4,5imidazo2,1-aisoquinoline) derivatives.
Ning et al. (Wed,) studied this question.