The review describes strategies for the synthetic search for new derivatives that exhibit activity against , including those that involve modification of the structure of substances used in modern medical practice. An approach based on the use of a pyrimidine nucleus as a basis for constructing a molecule with a pronounced antibacterial effect is characterized as promising in the design of new antimicrobial agents. The importance of introducing heterocyclic substituents into the molecule, which are related to “privileged” pharmacophores, is substantiated. It is shown that the construction of the structure of compounds by introducing these fragments, which are present in the molecule of compounds exhibiting a wide range of pharmacological activity, is determined by the concept of obtaining medicinal substances with a multitarget effect. The paper presents the author’s methods for obtaining substances with an anti- effect, based on the modification of the structure of previously studied compounds by introducing a heterocyclic substituent.
M.A. Samotrueva (Thu,) studied this question.