What question did this study set out to answer?

February 28, 2026

Chemoselective Oxidative Cross-Coupling of Secondary Phosphine Chalcogenides with Mercaptoalkanols: Synthesis of Hydroxyl-Containing Thioesters of Chalcogenophosphinic Acids

Key Points

To investigate the chemoselective oxidative cross-coupling of secondary phosphine chalcogenides with mercaptoalkanols.
Utilized CCl/EtN system for the reaction
Conducted reactions at mild temperatures (20–25°C)
Reactions lasted between 2 to 7 hours
Reagents were used in an equimolar ratio
Achieved yields of hydroxyl-containing thioesters between 76% to 89%
Reactions were found to be chemoselective
Produced thioesters of chalcogenophosphinic acids with free reactive hydroxyl groups

Abstract

The oxidative cross-coupling of secondary phosphine chalcogenides with mercaptoalkanols in the presence of the CCl/EtN system at an equimolar ratio of reagents proceeds chemoselectively under mild conditions (20–25°C, 2–7 h) to give the corresponding thioesters of chalcogenophosphinic acids, containing free reactive hydroxyl groups, in 76–89% yield.

Bookmark

Cite This Study

K.O. Khrapova (Wed,) studied this question.

synapsesocial.com/papers/69a286240a974eb0d3c00f61 https://doi.org/https://doi.org/10.7868/s3034630425080123

Bookmark