A halogenated pregnenolone analogue suppresses HepG2 proliferation and induces apoptosis via PPARγ regulation

Key Points

• The aim is to explore the anti-proliferative and pro-apoptotic effects of a halogenated pregnenolone analogue on HepG2 cells.
• Utilized HepG2 cell line for experiments
• Administered halogenated pregnenolone derivative 20
• Monitored cell proliferation and apoptosis
• Assessed PPARγ modulation
• Halogenated derivative 20 significantly reduced HepG2 proliferation
• Induction of apoptosis was observed in treated cells
• PPARγ regulation was confirmed as a pathway for the observed effects