Sustained Drug-Drug Interaction Between Cyclosporine and Apalutamide in a Patient With Metastatic Hormone-Sensitive Prostate Cancer: A Case Report and Evaluation of CYP3A4 Induction via Pregnane X Receptor Activation by Apalutamide.
Key Points
This research evaluates the interaction between apalutamide and cyclosporine, particularly focusing on the CYP3A4 induction.
Evaluation of drug interactions in a clinical case report.
Monitoring of CYP3A4 activity in response to apalutamide administration.
Observational analysis of patient responses to combined medication.
Apalutamide induced CYP3A4 via the pregnane X receptor pathway.
A sustained drug-drug interaction was observed with cyclosporine.
Careful monitoring is recommended for patients using CYP3A4 substrates.
Abstract
Apa induced CYP3A4 via the PXR pathway, leading to a sustained DDI with CsA. Careful monitoring is necessary when Apa is coadministered with CYP3A4 substrates.
Sustained Drug-Drug Interaction Between Cyclosporine and Apalutamide in a Patient With Metastatic Hormone-Sensitive Prostate Cancer: A Case Report and Evaluation of CYP3A4 Induction via Pregnane X Receptor Activation by Apalutamide. | Synapse