Biocatalytic synthesis of heterobiaryl sulfoxides: A comparative study between Baeyer-Villiger monooxygenases and unspecific peroxygenases

Key Points

• The study aims to compare the efficacy of unspecific peroxygenases and Baeyer-Villiger monooxygenases in the sulfoxidation of heterobiaryl sulfides.
• Investigated sulfoxidation using unspecific peroxygenases and Baeyer-Villiger monooxygenases.
• Tested various UPOs for their efficiency in converting sulfides.
• Analyzed reaction products to assess enzyme performance.
• Only specific unspecific peroxygenases showed effective conversion of heterobiaryl indole- and pyrrole-based sulfides.
• Baeyer-Villiger monooxygenases displayed complementary but varied activity in the sulfoxidation process.