Delta-AVG after TAVI independently predicted 1-year LVEF improvement with an OR of 1.04 per 1 mmHg increase and an optimal cut-off of 20.5 mmHg (AUC 0.723, p=0.002).
Observational (n=121)
No
Does a greater reduction in mean aortic valve pressure gradient (delta-AVG) predict 1-year LVEF improvement and long-term survival in patients with severe aortic stenosis and reduced LVEF undergoing TAVI?
In patients with severe aortic stenosis and reduced LVEF undergoing TAVI, a greater reduction in the mean aortic valve pressure gradient (delta-AVG ≥20.5 mmHg) is a strong predictor of 1-year LVEF recovery and improved long-term survival.
Effect estimate: OR 1.04 per 1 mmHg increase in delta-AVG (95% CI 1.01–1.07)
Absolute Event Rate: 45.1% vs 54.9%
p-value: p=0.002
Background: The relationship between the reduction in aortic valve pressure gradient (AVG) after transcatheter aortic valve implantation (TAVI) and improvements in left ventricular ejection fraction (LVEF) or long-term survival remains unclear.
Murakami et al. (Thu,) conducted a observational in Patients with severe aortic stenosis and left ventricular ejection fraction below 50% undergoing transcatheter aortic valve implantation (n=121). Transcatheter aortic valve implantation (TAVI) was evaluated on 1-year left ventricular ejection fraction (LVEF) improvement defined as ≥10% increase from baseline (OR 1.04 per 1 mmHg increase in delta-AVG, 95% CI 1.01–1.07, p=0.002). Delta-AVG after TAVI independently predicted 1-year LVEF improvement with an OR of 1.04 per 1 mmHg increase and an optimal cut-off of 20.5 mmHg (AUC 0.723, p=0.002).