What question did this study set out to answer?

The study aims to explore the chemical properties and applicability of a bicyclic pyrrolidine block in synthesizing Nirmatrelvir and related compounds.

February 28, 2026

A New Bicyclic Pyrrolidine Block for Nirmatrelvir and Analogues

Key Points

The study aims to explore the chemical properties and applicability of a bicyclic pyrrolidine block in synthesizing Nirmatrelvir and related compounds.
Synthesized the key block from (+)-3-carene.
Carried out enol-ethylation of a precursor ketone under specific conditions.
Utilized triethyloxonium tetrafluoroborate during synthesis.
Identified key chemical properties of the bicyclic pyrrolidine block.
Demonstrated a feasible synthesis route for Nirmatrelvir and analogues.

Abstract

To study the chemical properties and potential use in the synthesis of Nirmatrelvir and related compounds, a key block, ()-2-ethoxy-6,6-dimethyl-3-azabicyclo3.1.0hex-2-ene, which is readily available from (+)-3-carene and obtained by enol-ethylation of ()-6,6-dimethyl-3-azabicyclo3.1.0hexan-2-one with triethyloxonium tetrafluoroborate ((EtO)BF ), was proposed.

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Cite This Study

G.R. Sunagatullina (Wed,) studied this question.

synapsesocial.com/papers/69a287350a974eb0d3c02b87 https://doi.org/https://doi.org/10.7868/s3034630425080148

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