Magnetic-aminopropyltriethoxysilane-sulfanilamide: A New Functional Sorbent for Selective Preconcentration of Sulfonylurea Antidiabetic Drugs in Biological Samples

Key Points

• To establish a selective and sensitive method for quantifying gliclazide and glimepiride in biological samples.
• Utilized magnetic solid-phase extraction (MSPE) for sample preparation.
• Developed a functional sorbent using magnetic-aminopropyltriethoxysilane-sulfanilamide.
• Applied the method to trace analysis of antidiabetic drugs in biological samples.
• Achieved high sensitivity for gliclazide and glimepiride quantification.
• Demonstrated effective preconcentration of analytes from various biological samples.