IgE to Galactose-α-1,3-Galactose (α-Gal) and Relevance to Ustekinumab First-Dose Infusion Reactions and Allergenicity.

Key Points

• The research aims to evaluate the significance of pre-existing IgE to α-gal in relation to infusion reactions to ustekinumab.
• Screening for IgE levels specific to α-gal in patients with alpha-gal syndrome.
• Assessment of infusion reactions during ustekinumab administration.
• Patients with higher levels of IgE to α-gal experienced more infusion reactions.
• Proposing screening for α-gal sensitization may prevent adverse events during treatment.