Peritumoral-to-tumoral apparent diffusion coefficient ratio as a marker of tumor microenvironment activity across breast cancer molecular subtypes

Key Points

• To evaluate the peritumoral-to-tumoral apparent diffusion coefficient (p/tADC) ratio as a marker for tumor microenvironment activity in breast cancer.
• Examined the p/tADC ratio using preoperative MRI protocols.
• Analyzed its correlation with tumor aggressiveness across various breast cancer molecular subtypes.
• The p/tADC ratio indicated significant stromal and microenvironmental changes linked to tumor aggressiveness.
• Integration of the p/tADC ratio in MRI protocols may enhance risk stratification and personalized treatment plans.