A humanized NOG-EXL mouse model for producing severe fever with thrombocytopenia syndrome virus-reactive human antibodies.
Key Points
The aim is to develop a humanized mouse model for studying severe fever with thrombocytopenia syndrome virus and its human antibody response.
Created a humanized NOG-EXL mouse model
Evaluated humoral immunity against the virus
Isolated B cells for high-affinity human monoclonal antibodies
Avoided genetic engineering in the process
Demonstrated effective humoral immune response in the model
Facilitated isolation of specific human antibodies without genetic modifications
Provided a platform for further studies on antibody functionality
Abstract
This model provides a valuable platform for evaluating humoral immunity and isolating B cells using high-affinity human monoclonal antibodies without genetic engineering.
اسأل الذكاء الاصطناعي
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اسأل الذكاء الاصطناعي
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A humanized NOG-EXL mouse model for producing severe fever with thrombocytopenia syndrome virus-reactive human antibodies. | Synapse