What question did this study set out to answer?

To determine if myocardial microcirculation and lactate measurements can predict ventricular contractility after heart transplantation.

March 1, 2026

Myocardial Microcirculation Combined With Lactate Measurements Predicts Ventricular Contractility in a Canine DCD Orthotopic Heart Transplantation During Ex Situ Machine Perfusion

Key Points

To determine if myocardial microcirculation and lactate measurements can predict ventricular contractility after heart transplantation.
Analyzed LV-ESPVR following orthotopic heart transplantation with donation after circulatory death (DCD)
Used First-to-Last interval shift as a microcirculatory parameter
Measured lactate levels at the end of ex situ machine perfusion (EVBP)
Employed a linear model for analysis.
Found a significant linear relationship between LV-ESPVR and the microcirculatory parameter
Demonstrated that lactate levels are predictive of myocardial function
Indicated improved prediction of contractility outcomes using combined metrics.

Abstract

We conclude that the LV-ESPVR after orthotopic HTx with DCD seems to be predictable by combining the microcirculatory parameter First-to-Lastinterval shift during, and the Lacven at the end of EVBP in a linear model.

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