This study demonstrated that photoaging-related transcriptomic changes were detectable in artificial skin under a relatively low UVA dose (7 J/cm2/day; total 21 J/cm2) with minimal histological alterations. Furthermore, hydrogen may have a protective effect against UVA-induced cellular stress and senescence, via diffusion through the skin surface, suggesting its potential effectiveness in preventing photoaging. This study provides preliminary evidence that may contribute to the development of future translational research on the utility of molecular hydrogen in UVA-induced photoaging.
Kiyoi et al. (Sun,) studied this question.