According to the experimental method, complex 2a exhibited the strongest binding constant against DNA (1.84 × 104 M-1), while complex 2c demonstrated the highest BSA binding constant (2.83 × 104 M-1). Subsequent to molecular docking, and consistent with experimental findings, it was determined that all molecules exhibited interaction with the same DNA and BSA residues. Complex 2a demonstrated the strongest binding affinity against DNA, while complex 2c manifested the most robust interaction with a binding value of -8.09 kcal/mol. A thorough evaluation of the drug-likeness properties of the palladium(II) complexes was conducted using the SwissADME web tool.
Üstün et al. (Thu,) studied this question.
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