MicroRNA Nanocapsules for Modulating Macrophage Polarization to Promote Bone Repair

Key Points

• This research aims to explore how microrna-loaded nanocapsules can influence macrophage polarization to enhance bone repair.
• Utilized microrna-containing nanocapsules to target macrophages
• Assessed macrophage polarization towards M2 phenotype
• Evaluated the effects on bone repair in experimental models
• Nanocapsules effectively shifted macrophages from M1 to M2 phenotype
• Improved bone healing observed with M2-polarized macrophages
• Demonstrated significant enhancement in bone repair markers