What question did this study set out to answer?

This research aims to evaluate the diagnostic value of specific miRNAs in patients with acute pancreatitis.

March 1, 2026Open Access

Diagnostic Value of miR-21, miR-122, miR-145, and miR-146a in Acute Pancreatitis: Findings from the PASEVO Cohort in Southeastern Romania

Key Points

This research aims to evaluate the diagnostic value of specific miRNAs in patients with acute pancreatitis.
Analyzed miRNA levels in patients with various severity of acute pancreatitis.
Compared miRNA levels to standard diagnostic tools like CT scans and clinical scoring systems.
Employed the PASEVO cohort for data collection in Southeastern Romania.
miR-21, miR-122, miR-145, and miR-146a levels showed significant changes in acute pancreatitis.
These miRNAs demonstrated potential as biomarkers for diagnosing both mild and severe forms of acute pancreatitis.
The findings highlight the applicability of miRNAs in enhancing the diagnostic process.

Abstract

Acute pancreatitis (AP) is an inflammatory condition of the pancreas that initiates a cascade of inflammation, which can cause pancreatic damage or spread to other organs. The severity of AP ranges from mild acute pancreatitis (MAP) to severe acute pancreatitis (SAP). While standard diagnostic tools include contrast-enhanced CT scans, clinical scoring systems like APACHE II and Ranson, and laboratory tests, miRNAs have emerged as crucial regulators of gene expression involved in various physiological and pathological processes. Over the last decade, research has demonstrated that significant alterations in miRNA levels are integral to AP development. Since one miRNA can target multiple genes, they serve as key modulators of disease progression.

Diagnostic Value of miR-21, miR-122, miR-145, and miR-146a in Acute Pancreatitis: Findings from the PASEVO Cohort in Southeastern Romania

Key Points

Abstract

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