What does this research mean for the field?

Gram-negative bacteria dominate ICU infections, but resistance to gram-positive bacteria, especially VRE, has reached alarming levels. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

The study aims to analyze patterns of microbiological infections in ICU patients over a 14-year period.

March 2, 2026Open Access

Microbiological Landscape in Critical Care: 14-Year Analysis of 42,722 ICU Patients Using MIMIC-IV Database

Key Points

The study aims to analyze patterns of microbiological infections in ICU patients over a 14-year period.
Analyzed data from the MIMIC-IV database
Included information from 42,722 ICU patients
Examined trends in gram-negative and gram-positive bacterial infections
Identified a dominance of gram-negative bacteria in ICU infections
Noted alarming levels of resistance in gram-positive bacteria like VRE
Highlighted significant variation in infection patterns across different sites and units

Abstract

Gram-negative bacteria remain dominant in ICU infections, but gram-positive resistance-particularly VRE-has reached alarming levels. Variation across sites and units highlights the need for tailored empirical therapy. Implementing site- and unit-specific antibiograms could help reduce resistance and improve outcomes in critical care.

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Cite This Study

Biswas et al. (Sun,) studied this question.

synapsesocial.com/papers/69a528b3f1e85e5c73bf0341 https://doi.org/https://doi.org/10.1016/j.ijid.2026.108501

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