5-HT2A receptors in the prelimbic cortex VIP-expressing interneurons: A mechanism for psychedelic-induced innate fear attenuation.

Key Points

• Investigate how 5-HT₂A receptor activation influences innate fear through VIP interneurons in the prelimbic cortex.
• Administered 4-AcO-DMT to examine receptor activation effects
• Analyzed modulation of VIP interneurons in the prelimbic cortex
• Evaluated changes in innate fear responses
• 5-HT₂A receptor activation significantly reduced innate fear response
• VIP interneurons played a crucial role in mediating this effect