Because they control waste elimination, electrolyte composition, and fluid balance, kidneys are essential for preserving homeostasis. Acute and chronic kidney illnesses are largely caused by exposure to nephrotoxic substances, including medicines, environmental pollutants, and metabolic abnormalities. With a growing reliance on dialysis and a scarcity of kidney transplants, the prevalence of chronic kidney disease (CKD) is rapidly increasing both globally and in India. Despite their effectiveness, conventional treatments can have negative side effects and are expensive. Because of their long history of traditional use, affordability, and safety, herbal and plant-based medicines are gaining popularity. This review thoroughly identifies medicinal plants that have been shown to have nephroprotective potential against kidney damage caused by drugs and toxins. Antioxidant, anti-inflammatory, and free radical scavenging mechanisms are the main ways that plants like Allium sativum, Aloe vera, Azadirachta indica, Curcuma longa, Ginkgo biloba, Withania somnifera, and several others have nephroprotective benefits. Flavonoids, alkaloids, saponins, polyphenols, terpenoids, and glycosides are among the phytoconstituents that are accountable. The function of these medicinal herbs in maintaining renal structure and function is firmly supported by experimental and preclinical data. This study highlights the therapeutic potential of nephroprotective plants and encourages more research into them in order to create safer and more potent renal protective medicines.
Kumar et al. (Fri,) studied this question.