Fractal Complexity and Pigment Architecture of the Human Iris: A Comparative Analysis Using Box-Counting Dimension and Nevi Characterization

Formal pre-registration of the hypothesis that pigmented biological structures across different tissues (iris nevi and cutaneous nevi) share measurable fractal and geometric organization principles. Defines two candidate metrics: - ΔD: cross-tissue fractal correlation index (box-counting dimension) - ΔA: cross-tissue golden proximity index (Auric Index extension) Predicts corr (Dᵢris, Dₛkin) > 0 and corr (Aᵢris, Aₛkin) > 0 across cohort n ≥ 40, p < 0. 05. No code. Theoretical formulation only. Pre-registered to establish priority and date of formulation. Related records: - Iris pipeline v5. 1: https: //doi. org/10. 5281/zenodo. 18806604- Iris preprint: https: //doi. org/10. 5281/zenodo. 18781344- Phyllotaxis base: https: //doi. org/10. 5281/zenodo. 18760369 --- v3: Added UBIRIS v1 external validation results (6 subjects, DOI 10. 5281/zenodo. 18818697). Section 5. 7 updated with first Auric Index signal in unknown population subject (UBIRIS 174, A=0. 400, p=0. 979). References 16-17 added.