Ferroptosis Induction by Purple Sweet Potato Anthocyanins in T-cell Acute Lymphoblastic Leukemia: Combined Molecular Docking, In Vitro, and In Vivo Evidence

Key Points

• The research aims to investigate the role of purple sweet potato anthocyanins (PSPAs) in inducing ferroptosis in T-cell acute lymphoblastic leukemia (T-ALL).
• Combined molecular docking studies
• In vitro experiments using T-ALL cell lines
• In vivo studies in T-ALL models
• PSPAs effectively induce ferroptosis in T-ALL cells.
• Modulation of the SLC7A11/GPX4 pathway was observed.
• PSPAs demonstrated safety and therapeutic potential as anti-leukemia agents.