To evaluate the etiologies of patients with primary amenorrhea (PA) symptoms who applied to our clinic. To know the etiologies of the patients and ensure that they are counseled and managed properly, and to contribute to the literature. Data from 155 patients diagnosed with PA were retrospectively analyzed. Demographic characteristics, development of secondary sex characteristics, physical examination findings, hormone profiles (HP), imaging results, chromosome analysis and management methods of the patients were assessed. Patients were divided into three groups according to HP values.The mean age of the patients was 18.43 ± 3.0 years, 95.5% were single, 96.4% had developed secondary sex characteristics, 86.1% had normal vaginal examinations, 35.8% were in the normogonadotropic normogonadism group according to the HP classification, uterus and ovaries were present in 50% on imaging, and 33.5% received estrogen therapy. A normal karyotype was found in 71.9% of the patients analyzed for karyotype. Five patients were found to have 46,XY chromosomes and five patients had Turner syndrome and its variants. Based on our findings, the most common etiology of PA was normogonadotropic normogonadism, followed by hypogonadotropic hypogonadism; therefore, patients should be thoroughly evaluated for genital system anatomy and central nervous system, and karyotype analysis should be requested in patients when needed at the next line of treatment.
Gündüz et al. (Sat,) studied this question.