What question did this study set out to answer?

Assess the anticonvulsant effects and neurochemical restoration of Crassula ovata in a seizure model.

March 2, 2026Open Access

Anticonvulsant Potential of Crassula Ovata: In Vivo Assessment of Seizure Modulation, Neurochemical Restoration, and Behavioural Pharmacology in PTZ-Treated Rats

Key Points

Assess the anticonvulsant effects and neurochemical restoration of Crassula ovata in a seizure model.
In vitro antioxidant assays to measure DPPH scavenging activity
Acetylcholinesterase inhibition tested in vitro
In vivo seizure models induced by PTZ in albino rats
Administration of C. ovata extract at doses of 200 mg/kg and 400 mg/kg
C. ovata significantly delayed seizure onset compared to the PTZ group
Reduced seizure severity observed in treated rats
Treatment restored dopamine levels in the brain
Modulated AChE activity in the brain compared to control

Abstract

The present investigation evaluates the anticonvulsant potential of Crassula ovata through an integrated approach involving in vitro antioxidant assays, acetylcholinesterase (AChE) inhibition, and in vivo PTZ-induced seizure models in albino rats. The extract exhibited strong DPPH radical scavenging activity and moderate AChE inhibition in vitro, indicating the presence of bioactive constituents with neuroprotective potential. In vivo administration of PTZ produced rapid seizure onset, elevated seizure scores, and altered neurochemical levels. Treatment with C. ovata (200 mg/kg and 400 mg/kg) significantly delayed seizure onset, reduced seizure severity, restored dopamine levels, and modulated brain AChE activity compared to the PTZ group. These findings support the potential anticonvulsant and neurochemical-stabilizing properties of C. ovata, suggesting its suitability for further exploration as a natural therapeutic candidate for epilepsy.

اسأل الذكاء الاصطناعي

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