Methodological Challenges in Brain Stimulation Trials for Youth With Major Depressive Disorder

Key Points

• Challenges in methodology affect outcomes and interpretations of brain stimulation among youth.
• Trial analyses show significant adverse events alongside the application of brain stimulation techniques.
• This review discusses methodological issues in trials related to major depressive disorder in youth populations.
• The findings highlight the need for refined approaches to ensure safety and efficacy of interventions.