Structure-activity relationship of N-cyclopropylmethyl-7α-(m-methylaminophenyl)-6,14-endoethano-northebaine derivatives as G-protein-biased KOR-selective agonists

Key Points

• G-protein-biased kappa opioid receptor-selective agonists demonstrated promising activity.
• These derivatives show enhanced binding profiles compared to traditional opioids.
• Structure-activity relationship analysis was performed on northebaine derivatives.
• Findings indicate potential for developing safer pain management options.