Developing an advanced electrochemical biosensor based on AuNPs/CS@CNF/Gr for sensitive CcO assay toward mitochondrial toxicity warning in TCM

Key Points

• The biosensor achieves high sensitivity in detecting cobalt cytochrome c oxidase (CcO), indicating effective monitoring of mitochondrial toxicity.
• Detection limits demonstrate a range of 0.1 to 1.0 nM for CcO, showcasing the sensor's enhanced performance.
• Analysis of the sensor's construction incorporates gold nanoparticles, chitosan, and conductive nanofibers with graphene for improved detection.
• This development underscores the potential for future applications in toxicological assessments and therapeutic monitoring.