Comparative Proteomics Of Hepatocytes And Hepatic Cell Lines Using Swath-MS Reveals Significant Variations In Proteins Involved In Energy, Lipid, And Xenobiotic Metabolism

Key Points

• Significant variations in proteins linked to metabolism were identified across different hepatic cell lines.
• The analysis uncovered differences in lipid and xenobiotic metabolism proteins, highlighting cellular functional diversity.
• Assessment using untargeted global proteomics methods demonstrated clear distinctions in protein expression.
• These findings support the selection of specific hepatic cell lines for advancing research into metabolism mechanisms.