Multi-omics analysis reveals that FABP2 suppresses colorectal cancer progression by regulating sphingomyelin metabolism via the PPAR signaling pathway

Key Points

• FABP2 suppresses colorectal cancer progression by regulating sphingomyelin metabolism—an important pathway.
• The analysis showed a notable decrease in tumoral sphingomyelin in response to FABP2 modulation, influencing cancer signaling.
• Observational analysis utilized multi-omics techniques to study metabolic changes linked to FABP2 and PPAR pathway.
• Findings support the potential for targeting FABP2 in colorectal cancer therapies, indicating novel intervention strategies.