Early functional changes and plasma GFAP in Swedish families with Autosomal Dominant Alzheimer’s disease mutations

Key Points

• Plasma GFAP levels were significantly associated with functional changes in family members with Alzheimer's mutations.
• The analysis revealed notable correlations between GFAP levels and early functional impairments in this population.
• Observational study focusing on families with autosomal dominant Alzheimer's disease mutations assessed various biological markers over a timeline.
• Identifying these early biomarkers may enable better understanding and monitoring of Alzheimer's progression.