Role of peptidylarginine deiminase 2 in a murine model of traumatic brain injury

Key Points

• PAD2 blockade significantly improves outcomes following traumatic brain injury, enhancing recovery.
• The study identifies PAD2 as a viable target for developing neuroprotective therapies.
• In contrast, PAD4 blockade does not exhibit the same beneficial effects on recovery from traumatic brain injury.
• This research supports further investigation of PAD2 for developing new treatments in neuroprotection.