Effects of melatonin supplementation on blood glycemic indices in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

Key Points

• Melatonin supplementation lowers blood glycemic indices, offering potential advantages for glucose regulation.
• The meta-analysis identifies significant reductions in fasting blood glucose and insulin levels with melatonin use.
• Assessment used meta-analytic techniques across several randomized controlled trials to evaluate outcomes over varying dosages.
• Findings may enable new approaches in diabetes management, though further trials are necessary to confirm long-term effects.