Comparative analysis of clinical outcomes and short-term treatment response of sputum microbiome between eosinophilic and non-eosinophilic COPD acute exacerbation | Synapse
March 3, 2026Open Access
Comparative analysis of clinical outcomes and short-term treatment response of sputum microbiome between eosinophilic and non-eosinophilic COPD acute exacerbation
Key Points
Eosinophilic AECOPD patients show improved short-term clinical outcomes compared to non-eosinophilic cases.
The study observed significant differences in sputum microbiota responses to treatment in both groups.
Analysis based on patient reports complemented by microbiome profiling through sputum samples.
These findings suggest that recognizing eosinophilic inflammation may enhance personalized treatment approaches.
Abstract
Patients with eosinophilic AECOPD demonstrate better short-term clinical outcomes. The sputum microbiota in the eosinophilic and non-eosinophilic patients also respond differently to the treatment for AECOPD.