March 3, 2026

Copper-Assisted Oxidative One-Pot Heterodifunctionalization of Cyclopentane-1,3-diones

Key Points

The methodology enables the synthesis of multiple cyclopentenone derivatives efficiently, highlighting its broad applicability.
Key evidence includes the production of aminated and halogenated groups within a single step.
Assessment using a novel one-pot oxidative reaction relies on the NMe2 radical from DMF as a key intermediate.
This process simplifies the synthesis of complex compounds, potentially advancing organic chemistry.

Abstract

A novel one-pot oxidative heterodifunctionalization of saturated cyclopentane-1,3-dione has been developed via the aza-Michael addition of the NMe2 radical generated from DMF solvent for the first time. This methodology offers a straightforward approach for the synthesis of aminated, halogenated, and chalcogenated cyclopentenone derivatives using copper halide as the halogen source and dichalcogenides as the chalcogen source.

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Cite This Study

Dubey et al. (Tue,) studied this question.

synapsesocial.com/papers/69a75af9c6e9836116a217ad https://doi.org/https://doi.org/10.1021/acs.joc.5c02411

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