March 3, 2026

Visible Light-Induced Hydrosulfonylation of Terminal Alkyne with Sulfonyl Chloride via Collision Complex between Solvent and Substrate

Key Points

Hydrosulfonylation efficiently synthesizes vinyl sulfone-based compounds without catalysts.
The method exhibits a broad substrate scope and high effectiveness in producing biologically active molecules.
This innovation relies on a collision complex between solvent and substrate, driven by visible light.
It highlights new insights into photochemistry, advancing understanding of chemical synthesis techniques.

Abstract

Herein, we developed a visible light-induced hydrosulfonylation of terminal alkynes using sulfonyl chloride via a collision complex between solvent and substrate. Such a method features a broad substrate scope and demonstrates its effectiveness in the synthesis of biologically active molecules. This is the first report on the synthesis of vinyl sulfone-based compounds without any metal catalysts, extra oxidants, or additives and paves the way for an in-depth understanding of the lone pair-σ complex photochemistry between solvent and substrate.

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Visible Light-Induced Hydrosulfonylation of Terminal Alkyne with Sulfonyl Chloride via Collision Complex between Solvent and Substrate

Key Points

Abstract

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