March 3, 2026Open Access

Gastrodia elata fermentation alleviates methamphetamine-induced neuroinflammation and anxiety- and depression-like behaviors by regulating the PI3K-AKT signaling pathway

Key Points

Reducing neuroinflammation alleviates anxiety- and depression-like behaviors linked to methamphetamine exposure.
The study identifies the PI3K-AKT signaling pathway as a critical mediator of FGE's protective effects.
This analysis looks at behavioral and neurobiological outcomes in a controlled exposure context.
Findings may support the use of FGE in treating disorders related to methamphetamine use.

Abstract

This study demonstrates that FGE, a potential natural agent, alleviates anxiety- and depression-like behaviors induced by METH through the reduction of neuroinflammation in the hippocampus. The protective effects of FGE against METH-induced neuronal damage and behavioral deficits are likely mediated by the PI3K-AKT signaling pathway. These findings suggest FGE as a promising therapeutic strategy for METH-related neurological disorders.

Gastrodia elata fermentation alleviates methamphetamine-induced neuroinflammation and anxiety- and depression-like behaviors by regulating the PI3K-AKT signaling pathway

Key Points

Abstract

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