Comparative Analysis of AlphaFold2 Models and Intrinsic Disorder Illuminates Structural Divergence as a Symptom of Functional Divergence Across the Calmodulin Superfamily

Key Points

• Structural divergence indicates functional divergence, highlighting the relationship between structure and function.
• AlphaFold2 models demonstrate varying accuracy in predicting structures, particularly among disordered regions.
• Observational analysis focuses on the calmodulin superfamily, showcasing diverse functional roles across structures.
• Findings suggest strong implications for understanding evolution, especially in the context of protein functionality.