RNA networks of lysosomal-related biomarkers in Parkinson’s disease and their correlations with freezing of gait-associated genes | Synapse
March 3, 2026Open Access
RNA networks of lysosomal-related biomarkers in Parkinson’s disease and their correlations with freezing of gait-associated genes
Key Points
Freezing of gait-associated genes correlate with lysosomal biomarkers FGD4 and MAN2B1 in Parkinson's disease.
A strong association was found between FGD4 and gait-related symptoms, indicating its potential as a diagnostic marker.
Observational analysis highlights the role of RNA networks in understanding the molecular pathways of Parkinson's disease.
Further validation is needed to confirm these findings and explore their clinical significance.
Abstract
FGD4 and MAN2B1 act as lysosomal biomarkers associated with PD and exhibit strong correlations with genes involved in PD-related freezing of gait. This study offers novel insights into PD diagnosis.