Integrated metabolomics and network pharmacology identify AKT1 as the central hub for Nymphaea candida flavonoids against acute lung injury

Key Points

• AKT1 serves as a central hub in combating acute lung injury.
• Integrated metabolomics identified several key flavonoids from Nymphaea candida.
• The approach combines both network pharmacology and metabolic profiling techniques.
• Understanding this pathway may help develop targeted therapies for lung injury.