Improving a Plasma Biomarker Panel for Early Detection of Pancreatic Ductal Adenocarcinoma with Aminopeptidase N (ANPEP) and Polymeric Immunoglobulin Receptor (PIGR)

Key Points

• The detection accuracy for early-stage PDAC improves with the addition of ANPEP and PIGR to the plasma biomarker panel.
• Combining ANPEP, PIGR, CA19-9, and THBS2 increases sensitivity for identifying pancreatic ductal adenocarcinoma.
• Assessment based on retrospective phase II studies adds valuable context to prediagnostic biomarker evaluations.
• Findings indicate that additional biomarkers may enhance the reliability of pancreatic cancer screening methods.