A Comprehensive Review on Grignard Reaction

The Grignard reaction is a key approach in making hydro carbons. It is very important when planning and carrying out such experiment to know how much mount of the main product will form and what kind of byproducts might appear. Reliable information has been collected about how Grignard reagent (Mg compounds) reacts with different carbonyl compounds. Using this data, it is possible to make good predictions about the results. When Grignard reagent reacts with saturated carbonyl compounds, scientists can usually predict the product yield quite accurately. But, with unsaturated carbonyl compounds, the available data is limited, unclear and often conflicting. Because of this, it is very hard sometimes impossible to predict the product yield correctly. This research was done to help to fill that knowledge gap. The experiments used normal laboratory methods & equipment. Joseph. A Dixon.et.al revealed that unsaturated carbonyl compounds (crotonaldehyde & mesityl oxide) are easy to buy commercially. The other two (3,4 -dimethyl -3- pentene-2- one & 4- pentene-3-one) can be made in large amounts. The reaction of Grignard reagent with cinnamaldehyde is not reported to our knowledge. So, in this article we explore the similar reactions of Grignard reagent with alpha, beta unsaturated aldehydes as a reference.