bla TEM-1 and bla TEM-176 overexpression underlies atypical ampicillin/sulbactam resistance in non-ESBL Salmonella from raw chicken

Key Points

• Atypical resistance to ampicillin and sulbactam is linked to blaTEM overexpression, indicating a significant mechanism of resistance.
• The hyperproduction of β-lactamase enzymes contributes to this unusual resistance pattern observed in Salmonella isolates.
• Understanding this resistance mechanism is crucial for managing antibiotic strategies in food safety and public health.
• Further research is needed to characterize the exact host factors influencing blaTEM expression and resistance mechanisms.