The amygdala emerges as a key integrative node linking nociceptive, emotional, and autonomic processes in fibromyalgia and migraine. Through its influence on descending pain modulatory systems, amygdala-centered circuits play a critical role in pain chronification and affective sensitization. These findings support a circuit-based framework for chronic pain, highlighting the amygdala as a promising target for individualized, multimodal therapeutic strategies aimed at restoring adaptive emotional-nociceptive integration.
Zharova et al. (Wed,) studied this question.