March 3, 2026Open Access

Multi-omics analyses related to unfolded protein response in prostate cancer implicate pro-tumor role of IFRD1

Key Points

IFRD1 plays a significant role in the unfolded protein response and its implications for prostate cancer are profound.
The developed UPRRS prognostic model indicates potential for better personalized management in patients.
Single-cell atlas analysis reveals heterogeneity in the unfolded protein response across different prostate cancer cases.
Findings suggest that IFRD1 could serve as both a diagnostic marker and a target for therapeutic interventions.

Abstract

We provide the first systematic single-cell atlas of UPR heterogeneity in PCa and develop a clinically translatable UPRRS prognostic model. IFRD1, a key driver, emerges as a dual diagnostic and therapeutic target, offering both theoretical and experimental foundations for precision stratification and individualized management of PCa.

Multi-omics analyses related to unfolded protein response in prostate cancer implicate pro-tumor role of IFRD1

Key Points

Abstract

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