March 3, 2026Open Access

Acquisition of drug-resistance induces cytokine reprogramming in a human leukemic cell line. Role of p38 MAPK

Key Points

Cytokine reprogramming significantly contributes to drug resistance in pre-B leukemic cells, altering treatment responses.
Activation of p38 MAPK plays a crucial role in modifying cytokine secretion patterns during drug exposure.
Assessment using cytokine signatures helps identify potential prognostic markers for patients with resistant leukemia.
Findings suggest that targeting these signaling circuits may optimize treatment strategies for refractory cases.

Abstract

Together, our results suggest that cytotoxic drug-based treatments can modify the cytokine secretory pattern of pre-B leukemic cells, leading to a resistant phenotype through a mechanism that involves p38 MAPK activation. Defining the specific cytokine signatures and associated signaling circuits could provide valuable prognostic markers and aid in optimizing treatment strategies for refractory and/or relapsed patients.

Acquisition of drug-resistance induces cytokine reprogramming in a human leukemic cell line. Role of p38 MAPK

Key Points

Abstract

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