March 3, 2026Open Access

Discordance of Dopaminergic Dysfunction and Subcortical Atrophy by α‐Synuclein Status in Sporadic and Genetic Parkinson's Disease

Key Points

S+ patients show greater dopaminergic dysfunction compared to S- patients, indicating different disease processes.
Subcortical atrophy is more pronounced in S- patients, highlighting structural differences associated with α-synuclein status.
Analysis demonstrates a discordance between neurotransmitter function and brain structure in Parkinson's disease.
Understanding the relationship between α-synuclein status and its effects on pathology could improve biomarker development.

Abstract

S+ patients exhibit more dopaminergic deficit, whereas S- patients have more subcortical atrophy across sporadic and genetic PD. Together, our findings reveal structure/function and DAT/MRI discordance, providing insight into biomarkers and pathophysiology of synucleinopathy and PD. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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Cite This Study

Duong et al. (Wed,) studied this question.

synapsesocial.com/papers/69a75d0dc6e9836116a26780 https://doi.org/https://doi.org/10.1002/mds.70186

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