March 3, 2026Open Access

Intratumoral heterogeneity and chemotherapy-induced alteration of CLDN18.2 expression in resectable gastric cancer

Key Points

CLDN18.2 expression alters significantly post-chemotherapy in gastric cancer, showing a shift from positivity to negativity.
Biopsy and surgically resected specimens show concordant results in CLDN18.2 expression, indicating reliability in assessments.
The study reveals a high prevalence of heterogeneous expression of CLDN18.2 in gastric cancer tumors, complicating treatment decisions.
Findings highlight the need for personalized approaches in chemotherapy based on individual tumor characteristics.

Abstract

The CLDN18.2 expression demonstrated an acceptable concordance between biopsy and surgically resected specimens. However, high prevalence of heterogeneous expression and tendency for CLDN18.2 positivity to shift to negativity following chemotherapy existed.

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Cite This Study

Nagano et al. (Wed,) studied this question.

synapsesocial.com/papers/69a75d12c6e9836116a26829 https://doi.org/https://doi.org/10.1007/s10147-026-02972-w

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