March 3, 2026Open Access

The Effect of Pertussis Vaccination During Pregnancy on the Binding Epitopes and Avidity of Anti–Pertussis Toxin Immunoglobulin G Antibodies in Infants and Their Mothers

Key Points

Immunization during pregnancy decreases primary vaccination-induced antibody responses.
Infants exhibit different responses against pertussis toxin epitopes, indicating variability.

Structured PICO

Does pertussis vaccination during pregnancy affect primary vaccination-induced antibody responses in infants?

Population

Infants and their mothers

Intervention

Pertussis vaccination during pregnancy

Outcome

Binding epitopes and avidity of anti-pertussis toxin immunoglobulin G antibodiessurrogate

Maternal pertussis immunization alters the epitope specificity of the infant's antibody response to primary vaccination.

Abstract

Immunization during pregnancy decreased primary vaccination-induced antibody responses disproportionately against different PT epitopes in infants.The trial was registered in the EU Clinical Trial database (EudraCT number 2019-001986-34, https://www.clinicaltrialsregister.eu).

The Effect of Pertussis Vaccination During Pregnancy on the Binding Epitopes and Avidity of Anti–Pertussis Toxin Immunoglobulin G Antibodies in Infants and Their Mothers

Key Points

Structured PICO

Abstract

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