Molecular mechanisms of age-related vulnerability to traumatic brain injury

Key Points

• Increased neuroinflammation is observed following traumatic brain injury in older adults, highlighting a key pathway of vulnerability.
• Older age correlates with elevated oxidative stress and apoptosis after brain injury, where mechanisms may differ from younger individuals.
• Assessment of molecular mechanisms mediating age-related differences in traumatic brain injury responses elucidates potential targets for intervention.
• Understanding these age-specific vulnerabilities may pave the way for tailored treatments for older adults suffering traumatic brain injuries.