Aberrant topology of the default mode network is associated with phosphatidylcholine and triglyceride levels in major depressive disorder

Key Points

• Alterations in the default mode network are linked to triglyceride levels, indicating potential biomarkers for major depressive disorder.
• Notably, the betweenness centrality of the SFGmed.R shows significant correlation with phosphatidylcholine and triglyceride levels.
• Observational analysis highlights a crucial role of the SFGmed.R as a node in the default mode network among patients with major depressive disorder.
• Understanding these associations may unveil new insights into the pathophysiology of major depressive disorder.